GSDMD knockout alleviates hyperoxia-induced hippocampal brain injury in neonatal mice

Exposure to neonatal hyperoxia is associated with brain injury and poor neurodevelopmental outcomes in preterm infants. Our goal was to determine the pathogenic role of GDMD in hiipocampal in injury in newborn mice Overall design: Newborn GSDMD knockout mice and their wildtype littermates were randomized within 24 hours of birth to room air or hyperoxia (85%) from postnatal day 1 to 14. Samples were collected on P15.