Single-Cell Transcriptomics Unravels the Early Immune Landscape of Renal Allograft Rejection and Nominates Ccl3-Ccr5 as a Therapeutic Target

Conclusions Our study establishes an in-depth, early-stage immune landscape of renal transplantation, uncovering the Isg15+Mac subset as a critical driver of acute rejection via the Ccl3-Ccr5 axis. And also indicating that Maraviroc may potentially be a therapeutic candidate for transplant rejection.