Histatins: Saliva proteins with important functions for our innate immune system

Name: Histatins: Saliva proteins with important functions for our innate immune system
Creator: Lund University, Theoretical Chemistry, PO Box 124, 22 100, Lund, SE; Lund University, Department of Theoretical Chemistry, PO Box 124, 22 100, Lund, SE; Lund University, Department of Theoretical Chemistry, PO Box 124, 22 100 Lund, Sweden; Structural Biology and NMR Laboratory, Linder, Department of Biology, sbinlab, Ole Maaløes Vej 5 2200 København N., 2200, Copenhagen n, DK
Published: 2028-01-01T00:00:00+08:00

ESRF Portal2028-01-01 更新2026-04-23 收录

唾液蛋白质组学

先天免疫反应机制

数据链接：

https://doi.esrf.fr/10.15151/ESRF-ES-2001352989 数据链接链接失效反馈

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资源简介：

This study will focus on the Histatins (Hst), a family of saliva proteins that act as a first line of defence of our innate immune system and possess antiviral/antimicrobial/antifungal properties. Of specific interest are Histatin 1 (Hst1), Histatin 3 (Hst3), and Histatin 5 (Hst5). These peptides contain 38, 32, and 24 amino acids, respectively, of which the 22 first amino acids in the primary sequence are close to identical, barring a few deviations in Hst1. Here, we aim to understand from a biophysics perspective why Hst5 has a greater killing efficacy for fungi and microbes and less for a virus such as Influenza A (IAV). In contrast, the opposite relationship prevails for Hst1 and Hst3. The aim is to achieve a molecular understanding of the underlying physics and the structure-function relationship by utilizing the toolbox we have developed for more than a decade of research for Hst5, combining computer simulations and experiments.

提供机构：

Lund University, Theoretical Chemistry, PO Box 124, 22 100, Lund, SE; Lund University, Department of Theoretical Chemistry, PO Box 124, 22 100, Lund, SE; Lund University, Department of Theoretical Chemistry, PO Box 124, 22 100 Lund, Sweden; Structural Biology and NMR Laboratory, Linder, Department of Biology, sbinlab, Ole Maaløes Vej 5 2200 København N., 2200, Copenhagen n, DK

创建时间：

2028-01-01