Prevalence and treatment outcomes of latent tuberculosis infection among older patients with chronic obstructive pulmonary disease in an area with intermediate tuberculosis burden

Chronic obstructive pulmonary disease (COPD) and aging both increase the risk of tuberculosis (TB), an important infectious disease in human. Exploring the burden and predictors of latent tuberculosis infection (LTBI) and treatment outcomes for older individuals with COPD is essential to guide LTBI intervention policy. We enrolled patients aged over 60 years with COPD between January 2021 and June 2023 for LTBI screening using interferon-gamma release assay (IGRA). LTBI treatment options included all World Health Organization (WHO)-recommended regimens. The final regimen was selected through shared decision-making between patients and their COPD physicians, leveraging the long-standing rapport being established. We investigated the prevalence of LTBI in this population, identified risk factors using logistic regression analysis, and evaluated treatment outcomes. A total of 810 COPD patients (mean: 72.8-years) underwent LTBI screening, with an IGRA-positive rate of 23.8%. IGRA positivity was correlated with smoking pack-years (adjusted odds ratio [aOR]: 1.02, p p = 0.030), COPD duration (aOR 1.10, p = 0.03), inhaled corticosteroid use (aOR 3.06, p p