Differential gene expression in beta cells and non-beta cells from islets of NOD mice

Diabetes (T1D) is a disease in which the immune system destroys the insulin-producing beta cells. Recently, researchers have become interested in the role of the innate immune system in initiating this process. To further investigate this, we used RNA-seq to analyze sorted beta cells from non-diabetic and pre-diabetic female non-obese models of diabetes (NOD). These results shed light on the potential involvement of m6A mediators in the development of T1D, highlighting a promising avenue for future research. RNA-seq was performed on FACS sorted islet cells by autofluorescence beta and non-beta cells from NOD female mice.