VRprofile

The antibiotic resistance genes (ARGs) often gain mobility through associating with a set of mobile genetic elements (mobilome). Their concerted activities significantly contribute to the promiscuous spread of ARGs throughout the microbial community. Here, we report the release of VRprofile version 2.0, which offers three major enhancements: (i) graphical representation of the multiple resistance regions with mosaic structures and comparison to the known MGEs with similar architecture; (ii) aid to explore the relationships of antibiotic resistance genes, mobile elements, and host strains; (iii) pre-computed mobilome of more than 5500 ESKAPEE bacterial genomes.

抗生素抗性基因（antibiotic resistance genes, ARGs）通常通过与一组移动遗传元件（mobile genetic elements，移动组mobilome）结合获得移动性。二者的协同活动显著推动了ARGs在微生物群落中的无差别扩散。在此，我们发布VRprofile 2.0版本，该工具具备三大核心改进：（1）以可视化形式展示具有镶嵌结构的多重耐药区域，并与已知结构相似的移动遗传元件（mobile genetic elements, MGEs）进行比对；（2）辅助探索抗生素抗性基因、移动元件与宿主菌株之间的关联；（3）内置了超过5500个ESKAPEE细菌基因组的预计算移动组数据。

搜集汇总

背景与挑战

背景概述

VRprofile2是一个专注于细菌病原体中抗生素耐药性相关移动基因组检测的数据集，提供了图形化分析工具和预计算的ESKAPEE细菌基因组数据，旨在支持研究人员探索抗生素耐药性的传播机制。