Multi-stage expression in BBN mouse model reveals progression-associated molecular changes in basal/squamous and sarcomatoid bladder carcinogenesis

RNA-seq data of microdissected lesions occurring in C57BL/6 male mice treated with N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) and normal control urothelium from untreated mice. RNA-sequencing of 37 microdissected samples, including 29 lesions from 27 BBN-exposed mice representative of all stages of carcinogenesis - hyperplasia (n=4), dysplasia (n=5), CIS (n=3), pTa (n=5), pT1 (n=7), MIBC (n=5) - as well as 3 BBN-exposed urothelia of normal morphology (adjacent to hyperplasia) and 5 unexposed control urothelia.