Additional file 4: of Impaired glucose metabolism and altered gut microbiome despite calorie restriction of ob/ob mice

Table S1. Detailed information on when fresh fecal samples and cecum content were collected. Table S2. Associations between individual metabolic phenotypes and microbial alpha diversity measures using linear mixed models. Table S3. Testing for differences in the Shannon diversity index, observed ASVs, and Firmicutes to Bacteroidetes ratio between the groups during each week. FDR-adjusted p-values from Wilcoxon rank-sum test are reported. Table S4. Testing for differences in PC1 between groups during each week. FDR-adjusted p-values from Wilcoxon rank-sum test are reported. Table S5a-c. ASVs that are differentially abundant in pairwise comparisons of groups, consistently during W6-W9. Both p-values and Holm's sequential rejection-based adjusted p-values are reported. ASVs re-annotated with iMGMC are marked in the last column "Altered taxonomy". Table S6a-f. KEGG pathways (a-c) and orthologous groups (d-f) that are differentially abundant in pairwise comparisons of groups, consistently during W6-W9. Both p-values and Holm's sequential rejection-based adjusted p-values are reported. Table S7a-b. Spearman rank correlations between microbial taxa and one-time metabolic measurements, estimated separately for the groups. Taxa with at least one correlation with FDR-adjusted P