Characteristics of Malian HbAA, HbAS, and HbAC children from which parasite isolates were obtained.

The number of samples (n), proportion of samples with α-thalassemia (wildtype, WT; heterozygous, HET; not determined, ND) and G6PD*A- (G202A) (absent, ABS; heterozygous, HET; hemizygous, HEM) genotypes, mean age (years), median parasite density (/μl), and proportion of severe malaria cases are shown for all HbAA, HbAS, and HbAC samples used in comparisons, and unique HbAA, HbAS, and HbAC samples used in comparisons. All samples (n = 62) include 10 parasite strains that were used in multiple comparisons, while unique samples include 52 parasite strains that were used in single comparisons. Three unique samples (2 HbAS and 1 HbAC) were classified as severe since they met one or more of these criteria: cessation of eating/drinking, repetitive vomiting, or prostration.