RNA-seq to characterize estrogen receptor alpha mutation in the female rat right ventricle with pressure overload

Conclusions: ERα in females is protective against RV-pulmonary vascular uncoupling, diastolic dysfunction, and fibrosis in response to pressure overload. ERα appears to be dispensable for RV adaptation in males. ERα may be a mediator of superior RV adaptation in female patients with PAH.研究结论：雌性个体中的雌激素受体α（ERα）可在压力负荷刺激下，对右心室-肺血管失耦联、舒张功能障碍及纤维化病变起到保护作用。雄性个体的右心室适应过程似乎并不依赖ERα。ERα或可作为肺动脉高压（PAH）女性患者实现更优右心室适应的介导因子。