Clinical and demographic characteristics of the subjects meeting all inclusion criteria and having DNA available for genotyping.

1. Nephropathy = microalbinuria or proteinuria or end-stage renal disease (dialysis) due to diabetic nephropathy.2. p value comparing Nephropathy and No-Nephropathy subsets of same population.3. p value comparing total primary population to total Replication Population.4. p value comparing prevalence of nephropathy in the 2 populations.5. Age, age at DM diagnosis, years of DM, HbA1c, BMI are expressed in mean ± SD.6. Retinopathy = For primary population retinopathy defined as proliferative retinopathy or macular edema; For replication population retinopathy defined as background or proliferative retinopathy or macular edema.7. CHD = coronary heart disease, CABG = coronary artery bypass graft, PCI = percutaneous coronary intervention, MI = Myocardial infarction.