Epidemiologic Architecture for Genes Linked to Environment (EAGLE) MetaboChip Study

The Epidemiologic Architecture for Genes Linked to Environment (EAGLE) study is a study site of the larger Population Architecture using Genomics and Epidemiology (PAGE) I study.  EAGLE accessed two data resources during the course of study: the National Health and Nutrition Examination Surveys (NHANES) and BioVU, the Vanderbilt University Medical Center biorepository linked to de-identified electronic health records.The EAGLE MetaboChip Study, also known as EAGLE BioVU in the literature, is a data resource of Illumina MetaboChip genotypes for ~15,000 DNA samples from African American/Black, Hispanic, and Asian patients in BioVU (PMID: 26201699). Several EAGLE BioVU and PAGE I study phenotypes were extracted using structured and unstructured data available in de-identified electronic health records linked to the DNA samples.  ]]>
DNA samples were pulled from the larger Vanderbilt University Medical Center biorepository based on race/ethnicity recorded in the electronic health record. We intentionally prioritized Illumina MetaboChip genotyping for DNA samples from patients with reported race other than European American (White). Race/ethnicity data in the Vanderbilt University Medical Center electronic health record is primarily administratively assigned (PMID: 20733501).]]>
The larger PAGE I study and its study sites were funded in 2008 by NHGRI/NIH. The initial PAGE I study focused on genotyping diverse populations drawn from cross-sectional and cohort studies to replicate genome-wide association study (GWAS) index variants identified in European-descent populations (PMID: 21836165). Initial PAGE I study genotyping efforts included the Centers for Disease Control and Prevention's NHANES, which allowed limited, targeted genotyping in this cross-sectional resource.  With American Recovery and Reinvestment Act of 2009 (ARRA) funding, the PAGE I study expanded its research activity to fine mapping GWAS-identified regions (PMID: 22539988). To contribute to the planned fine-mapping efforts as part of PAGE I, EAGLE genotyped ~15,000 DNA samples from patients with race other than White in BioVU, the Vanderbilt University Medical Center biorepository linked to de-identified electronic health records, using the Illumina MetaboChip. Also under ARRA funding, EAGLE accessed BioVU to identify cases and controls for specific common cancers to contribute to the larger PAGE I study efforts to replicate GWAS-identified index variants for these phenotypes (PMID: 23424142).]]>