Comparison of epitopes and neutralization potency of mAbs recognizing domain III of DENV E protein.
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*Potent neutralizing mAbs against DENV2 and DENV1 were defined by PRNT50 ≤311 µg/ml and ≤590 µg/ml, respectively. Most of the potent neutralizing mAbs were generated by immunization of IFN-α/β R -/- C57BL/6 mice with DENV twice and booster with recombinant domain III [33], [34] , whereas most of the less potent neutralizing mAbs were generated by immunization of WT BALB/c mice [29], [30], [32], [38]–[42].
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2015-12-02
