Identification of ubiquitination sites on protein CSDE1 in SHSY5Y cells.

This bottom-up proteomics dataset provides a global map of post-translational modifications (PTMs) on the RNA-binding protein CSDE1 in human neuroblastoma SHSY5Y cells. The data was acquired to survey the modification landscape of CSDE1, with a particular observation that lysine (K) residues displayed the most abundant modification signals among all amino acids. This unbiased survey informed subsequent functional studies investigating the role of specific modification sites. The relationship between CSDE1 and the E3 ligase MKRN2 was established in our prior research.