mRNAs encoding IL-12 and a decoy-resistant variant of IL-18 synergize to engineer T cells for efficacious intratumoral adoptive immunotherapy
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE206195
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资源简介：
Mixtures of pmel-1 TCR-transgenic T cells electroporated with scIL-12 or DRIL-18 mRNAs exerted powerful therapeutic effects on injected and distant melanoma lesions. These effects are associated with T-cell metabolic fitness, changes in glycosylation of surface proteins gaining adhesiveness to E-selectin and enhanced miR-155 control on immunosuppressive target genes. Samples are pre-activated pmel-1 T cells with gp100 antigen and electropored with the indicated mRNA. RNA was extracted 24h later for bulk RNAseq analysis. contributor: Macrogen
创建时间：
2023-04-04
