Liver metastases originating from 4 colorectal cancer patients (CRC-LM).

Using liver metastases from 4 colorectal cancer patients (CRC-LM), we explored one receptor: EGFR whose signaling triggers cell proliferation and is exacerbated in many tumors. Overall design: We performed Spatial Transcriptomics using 10X Genomics Visium in these four different cancer patients and focused on ligand receptor interactions. For some patients, we were also able to perform validations by immunofluorescence. All patients were treated with neo-adjuvant chemotherapy prior to surgery and sample collection.