Sequencing of candidate positively-selected regions in the human genome

The project aims to investigate evolutionarily-interesting regions of the human genome. These often show signals of positive natural selection. Resequencing the same region of DNA in multiple humans provides a complete catalogue of the variants it contains and their distribution in the sample, and is the best basis for characterising positive selection. We have chosen a number of regions of the genome that are either of known evolutionary interest, or that show a possible signal of selection that we want to investigate further, along with some controls, and are resequencing them in a population sample of 30. Our analyses will extract information on neutral and selective aspects of the evolutionary history of these regions.