Effect of DOX on rat physical parameters and EF measurements (mean ± standard error of the mean.

Number of animals in treatment group at any given time is indicated within the parentheses.Average appearance score of animals in study, where 1 = excellent, active; 2 = good: active, slight hair loss; 3 = fair: less active, slight bloating; 4 = poor: reluctant to move, poor appetite and diarrhea; 5 = critical: marked pallor, lethargic.*increase in weight relative to baseline p**decrease in weight relative to baseline p≤0.001#increase in appearance score relative to baseline p†decrease in LVEF relative to baseline p = 0.005‡decrease in LVEF relative to baseline p = 0.01