A Concise Synthesis of the Octalactins
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https://figshare.com/articles/dataset/A_Concise_Synthesis_of_the_Octalactins/3348652
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资源简介：
The total synthesis of octalactins A and B has been achieved in 15 steps (longest linear sequence)
and 10% overall yield from commercially available materials. Key steps include the Paterson−Aldol reaction
for the rapid assembly of the carbonate 46, methylenation of 46 and subsequent Claisen rearrangement
of the corresponding alkenyl-substituted cyclic ketene acetal to provide the core unsaturated medium-ring
lactone 47, and the use of enzyme-mediated acetate deprotection in the presence of a medium-ring lactone.
创建时间：
2004-02-25
