Umbilical Vein CD4+T-Cell Signatures as Predictors of Gut Microbiota Dysbiosis in Gestational Diabetes Mellitus-Exposed Neonates
收藏科学数据银行2025-08-29 更新2026-04-23 收录
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资源简介：
Our study reveals a novel immune-mediated mechanism by which gestational diabetes mellitus (GDM) alters neonatal gut microbiota colonization, with potential implications for early-life microbiome programming and metabolic health. By integrating 16S rRNA sequencing of meconium and flow cytometric analysis of umbilical vein blood, we demonstrate that GDM induces a Th2/Th1 immune imbalance in neonates, which drives pro-inflammatory microbial shifts and depletes beneficial taxa. Mediation analysis further identifies CD4⁺T cell subsets and cytokines as significant mediators of GDM-microbiota associations.
提供机构：
Kaihong Zeng; Huanling Yu; Yandi Zhu; Shanxi Province Cancer Hospital; Xuanwu Hospital of Capital Medical University; Yuchen Wei; Xiaopei Qin; Capital Medical University; Qinyu Dang; Xiaxia Cai; Yulu Zhang; Yadi Zhang; Zhaoyang Chen
创建时间：
2025-08-29
