General characteristics of study population.

Malaria and HIV remain major public health challenges in sub-Saharan Africa. This study described the spectrum of malaria in people living with HIV (PLHIV) and HIV-negative adults in Gabon, where both diseases are endemic.MethodsA cross-sectional study was conducted at the Centre Hospitalier Universitaire de Libreville from September 2021 to October 2022. Asymptomatic and febrile PLHIV and HIV negative volunteers were screened for malaria and Plasmodium-infected individuals enrolled in the study. Data collected included socio-demographic characteristics, clinical presentation, cotrimoxazole use, antiretroviral treatment, and laboratory parameters, such as parasitaemia, haemoglobin levels and CD4+ cell counts. Data from PLHIV and HIV-negative participants were compared using bivariate and multivariable logistic regression analysis.ResultsAmong the 1.192 individuals tested, 513 were PLHIV and 599 HIV-negative. Overall, 56 Plasmodium falciparum-infected PLHIV and 66 HIV-negative individuals were enrolled. Asymptomatic malaria was more frequent among HIV-negative participants (60.6% vs 25.0%), while severe malaria was significantly more common among HIV-positive patients (48.2% vs 12.1%) (p Plasmodium falciparum parasitemia (p = 0.03). The median CD4 + cell count was significantly lower in PLHIV with severe malaria (150 [IQR: 90-204] cells/µL) compared to those with asymptomatic (304 [IQR: 189-476] cells/µL) (p = 0.018).ConclusionCompared to HIV negative, asymptomatic malaria was less frequent while severe malaria predominantly affects PLHIV with advanced immunosuppression, highlighting the importance of early detection and management of co-infection to reduce morbidity. Further studies are needed to investigate the neurological manifestations and the impact of prophylactic strategies in Libreville.