MeDIP-chip of adult mouse hippocampus exposed to neonatal ethanol
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE71313
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In this experiment, we exposed mice to ethanol injections on postnatal days 4 and 7. We then extracted whole-hippocampus on postnatal day 70. We performed MeDIP-chip using an antibody against 5mC. We also perfomed MEDME anaylsis using a chip with fully methylated DNA to act as a control. We found alterations in both modifications at many sites, including oxidative stress genes and imprinted loci. We also found many affect lipid metabolism pathways. Comparision of neonatal ethanol-injected with saline injected C57BL/6J mouse hippocampus in adulthood (day 70)
创建时间：
2016-08-16
