Fiber Optic Theranostics (FOT): The interstitial fiber-optic needles for cancer sensing and therapy

We investigate tumor
detection by using the hypoxia-sensitive fluorescent fiber to realize the fast
and accurate tumor recognition and diagnosis. We further perform the tumor
treatment by exploiting the endogenous photothermal effect of the
rare-earth-doped optical fibers, which are minimally intervened into the solid
tumor. The suppression and eradication of tumor xenografts significantly
validate the availability of the presented tumoricidal fiber. Our strategy opens horizons to inspire the design of optical
fiber-mediated “plug and play” precise tumor theranostics, which may intrigue broader fields, such as fiber
optics, materials, chemistry, medicine, and clinics.