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Loss of DNA replication control is a potent initiator of gene amplification

ChEBI2011-05-17 更新2026-07-21 收录

DNA复制调控

基因扩增

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-22018 数据链接链接失效反馈

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Loss of DNA replication control is a potent initiator of gene amplification

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创建时间：

2011-05-17

基因扩增

药物耐药性

Amplifications, regions of focal high level copy number change, lead to overexpression of oncogenes or drug resistance genes in tumors. Their presence is often associated with poor prognosis; however

NIAID Data Ecosystem70

Rtf2 is Important for Replication Fork Barrier Activity of RTS1 via Splicing of Rtf1 [cDNA-Seq]

DNA复制调控

RNA剪接

This study investigated the role Rtf2 plays on the replication fork barrier (RFB) activity of RTS1 in S. pombe. We confirm Rtf2 is important for the full barrier activity of the RTS1-Rtf1 RFB. We show

NIAID Data Ecosystem50

PCR primers for amplification of mtDNA and nuclear genes.

PCR引物设计

基因扩增

PCR primers for amplification of mtDNA and nuclear genes.

NIAID Data Ecosystem40

ChIP-Seq of gamma-H2Av bound to third instar salivary gland DNA in WT and SuUR mutant Drosophila; ChIP-Seq of SUUR and Cdc45 bound to egg chamber DNA from early and late stage egg chambers. Drosophila melanogaster

染色质免疫沉淀测序

DNA复制调控

We analyzed gamma-H2Av ChIP-Seq from hand dissected salivary glands of wandering third instar larvae from wild-type (OrR) or suppressor of under-replication (SuUR) mutant Drosophila. Goals were to det

NIAID Data Ecosystem60

Crystal structure of YabA amino-terminal domain from Bacillus subtilis

蛋白质晶体

DNA复制调控

Crystal structure of YabA amino-terminal domain from Bacillus subtilis Descriptor: Initiation-control protein YabA Authors: Cherrier, M.V, Bazin, A, Jameson, K.H, Wilkinson, A.J, Noirot-Gros, M.F, Ter

Protein Data Bank Japan2024-05-08 更新50

Loss of DNA replication control is a potent initiator of gene amplification

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