Average number of loose/watery stools per week by treatment group over the 4-week crofelemer study period in neratinib-induced diarrhea in dogs (n = 8 per treatment group).

Diarrhea was induced by daily doses of neratinib, and fecal scores using the Purina Fecal Scoring (PFS) System were collected daily for 28 days (4 weeks). Dogs were dosed with 40 mg of neratinib orally once daily for the first 5 days followed by daily doses of 80 mg of neratinib for 23 days. Stool consistency was dichotomized into loose/watery stools (defined as scores of 6 or 7 on the PFS) and non-diarrheic (scores 1 through 5 on the PFS).