Dissecting the stem cell compartment in Csnk1a1 haploinsufficiency
收藏NIAID Data Ecosystem2026-03-13 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE165395
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资源简介：
We sorted hematopoietic progenitors from mouse bone marrow previously transplanted with either Csnk1a1 fl/+ or Mx1Cre+ bone marrow and performed scRNAseq. We identified cell populations in a continuum of differentiation from quiescent stem cell to cycling lineage-marker expressing progenitor. Our analysis revealed signaling changes in primitive stem cells with Csnk1a1 haploinsufficiency that result in downregulation of inflammatory NFkB signaling while upregulating Myc and E2f dependent pro-proliferative pathways We used scRNA 3' RNA sequencing product from 10x Genomics to investigate the stem cell compartment in murine models of Csnk1a1 haploinsufficiency
创建时间：
2022-03-01
