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Sam68 regulation of alternative splicing in the developing cerebellum

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NIAID Data Ecosystem2026-04-25 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP212777
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We uncover a Sam68-dependent splicing program during cerebellar development. These events direct proper isoform expression of the genes required to guarantee the establishment of the correct spatial/temporal neural circuitry. The dysregulation in Sam68 null mice leads to functional defects in adult neurons Overall design: Examination of 3 different RNA from P1, P10 and P30 wild type cerebella of mouse, and 2 from P1 and P10 Sam68 null cerebella
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2020-09-02
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