CCDB_7351.jpg

Regulation of cytoplasmic calcium is crucial both for proper neuronal
function and cell survival. The concentration of Ca2+ in cytoplasm of a
neuron at rest is >10,000 times lower than in the extracellular
space, pointing to the importance of the transporters that extrude
intracellular Ca2+. The family of plasma membrane calcium-dependent
ATPases (PMCAs) represent a major component of the Ca2+ regulatory
system. However, little information is available on the regional and
cellular distribution of these calcium pumps. We used
immunohistochemistry to investigate the distribution of each of the four
PMCA isoforms in the rat brain.