Yap dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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Hippo signalling has been implicated as a key regulator of tissue regeneration. In the intestine, ex vivo organoid cultures model aspects of crypt epithelial regeneration. Therefore in order to uncover the Yap regulated transcriptional programs during crypt regeneration we performed RNA-sequencing of Yap wt and Yap deficient organoids, as well as organoids inducibly expressing Yap.
提供机构：
University of Massachusetts Medical School
创建时间：
2022-02-20
