Cinnamaldehyde can select mutants of Pseudomonas aeruginosa resistant to antibiotics

This study focused on the ability of Pseudomonas aeruginosa to resist to toxic concentrations of cinnamaldehyde (CNA, the main compound of cinnamon essential oil): 10 mutants have been selected and their genome have been sequenced in order to identify the mechanisms implicated. A-type mutants (CNA-A1, A2 and A3) resulted from exposure to stable concentration of CNA (900 microg/mL) for 10 days. B-type mutants resulted from exposure to increasing concentrations of CNA (from 900 to 1400 microg/mL): CNA-B1, B2 and B3 were selected 5 days post-exposure (reaching 1100 microg/mL CNA) and CNA-B4, B5, B6 and B7 were selected 10 days post-exposure (reaching 1400 microg/mL CNA).