Host Factor Experiment (FLX0001-siXRN2)
收藏DataCite Commons2020-07-23 更新2024-07-13 收录
下载链接：
https://www.fludb.org/brc/svExperimentDetails.spg?expAccession=IRD_MSSM_FLX0001-siXRN2&decorator=influenza&context=1593191205811
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资源简介：
The human helicase senataxin (SETX) has been linked to the neurodegenerative diseases amyotrophic lateral sclerosis (ALS4) and ataxia with oculomotor apraxia (AOA2). Here we identified a role for SETX in controlling the antiviral response. Cells that had undergone depletion of SETX and SETX-deficient cells derived from patients with AOA2 had higher expression of antiviral mediators in response to infection than did wild-type cells. Mechanistically, we propose a model whereby SETX attenuates the activity of RNA polymerase II (RNAPII) at genes stimulated after a virus is sensed and thus controls the magnitude of the host response to pathogens and the biogenesis of various RNA viruses (e.g., influenza A virus and West Nile virus). Our data indicate a potentially causal link among inborn errors in SETX, susceptibility to infection and the development of neurologic disorders.
提供机构：
Influenza Research Database
创建时间：
2020-06-26
