gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6

Neurotrophin or proneurotrophin signalling promotes p75NTR cleavage by gamma-secretase, allowing the release of p75 ICD and NRIF. This mechanism was shown in sympathetic neurons.<br>Gamma-secretase can be activated in a number of ways, including signalling via p75NTR. The phorbol esther PMA induces p75 cleavage, followed by NRIF nuclear translocation, after 30 min. Neurotrophin binding to p75, instead, triggers the same events only after 12 h.

神经营养素或前神经营养素信号传导促进p75NTR被γ-分泌酶切割，从而释放p75 ICD和NRIF。该机制已在交感神经元中得到证实。γ-分泌酶可通过多种方式被激活，包括通过p75NTR的信号传导。磷酰胆碱酯PMA诱导p75切割，随后NRIF进入细胞核转位，需时30分钟。相反，神经营养素与p75的结合，则仅在12小时后触发相同的事件。