Functional analysis of histone methyltransferase SETD8 in endometrial cancer
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下载链接：
https://www.ncbi.nlm.nih.gov/sra/DRP009168
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资源简介：
Endometrial cancer is the most common gynecological cancer. SETD8 is a histone methyltransferase that methylates lysine 20 of histone H4 (H4K20) and has been reported to be involved in human carcinogenesis by methylating non-histone proteins such as p53. In this study, we investigated how SETD8 causes cancer through histone methylation and p53 methylation. As a method, we performed RNA-seq and ChIP-seq using SETD8 knockdown endometrial cancer cell lines to investigate the gene regulatory function upon H4K20 monomethylation.
创建时间：
2022-11-03
