Prognostic significance of the angiopoietin-2 for early prediction of septic shock in severe sepsis patients: supplementary data

Aim: The current study investigated the plasma levels of angiopoietin-1/-2 and their association with
clinical outcomes of sepsis. Methods: Angiopoietin-1 and -2 levels were quantified in plasma from 105
patients with severe sepsis by ELISA. Results: Angiopoietin-2 levels elevated according to the severity of
sepsis progression. Angiopoietin-2 levels were correlatedwithmean arterial pressure and platelets counts,
total bilirubin, creatinine, procalcitonin, lactate levels and SOFA score. Angiopoietin-2 levels accurately
discriminated for sepsis with an AUC = 0.97 and septic shock from severe sepsis patients (AUC = 0.778).
Conclusion: Plasma angiopoietin-2 levels may serve as an additional biomarker for severe sepsis and septic
shock.