CYP2B6 haplotypes associated with D2cotinine/(D2cotinine+ D2nicotine) in a multivariate regression model with CYP2A6 haplotypes.

athe probability that the parameter estimate is different by chance from the reference, i.e. all CYP2A6 (n = 271) and CYP2B6 (n = 126) alleles not included in the multivariate regression. All CYP2A6 alleles presented are loss-of-function alleles associated with reduced metabolism (−) relative to the reference CYP2A6 alleles; all CYP2B6 alleles presented are associated with increased metabolism (+) relative to the reference (rs8109525G) CYP2B6 alleles. rs8109525 is in high linkage disequilibrium with rs8100458 (R2>0.95).