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Dnmt3l-knockout donor cells improve somatic cell nuclear transfer reprogramming efficiency

ChEBI2015-08-01 更新2026-07-12 收录

基因编辑优化克隆

体细胞核移植重编程

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-69007 数据链接链接失效反馈

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资源简介：

Dnmt3l-knockout donor cells improve somatic cell nuclear transfer reprogramming efficiency

应用场景：

创建时间：

2015-08-01

体细胞核移植重编程

猪克隆效率优化

Pig cloning by somatic cell nuclear transfer (SCNT) frequently undergoes incomplete epigenetic remodeling during the maternal-to-zygotic transition, which leads to a significant embryonic loss before

NIAID Data Ecosystem50

Single Cell Sequencing Identifies Key Epigenetic Regulators in Nuclear Transfer Mediated Reprogramming [ChIP-seq]. Mus musculus

体细胞核移植重编程

组蛋白修饰

Differentiated cell can be reprogrammed into totipotent embryo through somatic cell nuclear transfer (SCNT). However, this process is highly inefficient and most cloned embryos arrest at certain devel

NIAID Data Ecosystem40

Somatic cell nuclear reprogramming by mouse oocytes endures beyond reproductive decline. Mus musculus

体细胞核移植重编程

卵母细胞衰老

The mammalian oocyte has the unique feature of supporting fertilization and normal development while being able of reprogramming the nuclei of somatic cells towards pluripotency and occasionally even

NIAID Data Ecosystem30

Differences in the epigenetic modification of somatic cloned cattle from different types of donors still exist after reprogramming and differentiation

体细胞核移植重编程

动物表观遗传学

To investigate the differences in the epigenetic modification of somatic cloned cattle from different types of donors after reprogramming and differentiation,we established Six cell lines of cloned ca

NIAID Data Ecosystem50

Unreprogrammed H3K9me3 prevents minor ZGA and lineage commitment in SCNT embryos

体细胞核移植重编程

胚胎表观遗传调控

Supplemental Information

Figshare2023-08-10 更新30