Gut microbiota Raw sequence reads. Mouse

Investigations involving high-intensity interval training (HIIT) have proven to beefficient in controlling diabesity. This study aimed to assess the impact of discontinuingHIIT and retraining within the context of diabesity. 75 C57BL6 mice went through 5stages: baseline, induction of diabesity with Western diet, training, detraining, andretraining (6 weeks each period). Detraining led to elevated adiposity, exacerbatedmetabolic parameters and intestinal health, and altered gut microbiota composition.Retraining restored blood glucose regulation and enhanced intestinal health yet did notinduce fat reduction. While both training and retraining exerted an effect on thecomposition of the gut microbiota, the impact of diet demonstrates a more substantialpotency compared to that of exercise concerning intestinal health and microbiome.These findings may contribute to a broader understanding of diabesity management andintroduce perspectives for the use of specific physical training to enhance patientoutcomes and intestine health.