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Mutations in known Sma/Mab pathway genes specifically suppress the <i>sma-9</i> M lineage phenotype.

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NIAID Data Ecosystem2026-03-08 收录
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Suppression was scored based on the re-appearance of M-derived CCs, which are missing in sma-9(cc604) mutant. All animals listed in this table are homozygous for sma-9(cc604) except in the case of let-381(RNAi). ND: not determined. a The worms scored are homozygous for sma-9(cc604) and homozygous for the mutation indicated. b The worms scored are homozygous for sma-9(cc604) and heterozygous for the mutation indicated. c Data from [20]. All mutations are apparent null alleles. d Data from [21]. jj4 is an apparent null allele of drag-1. e Data from [22]. e1430 is an apparent null allele of unc-40. f The worms scored are wild-type worms or sma-3(jj3) worms treated with let-381(RNAi) post-embryonically (see Materials and methods). let-381(RNAi) leads to the loss of M-derived CCs [33]. g The numbers shown refer to percentages of worms with 2 M-derived CCs, which likely resulted from inefficient let-381(RNAi). Mutations in known Sma/Mab pathway genes specifically suppress the sma-9 M lineage phenotype.

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2015-05-15
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