Comparative Proteomic Analysis of Heterozygous and Null DAT Knockout Rats

Anastasia N. Vaganova, Zoya S. Fesenko, Sergey V. Shabelnikov, Alexey G. Mittenberg, Anna B. Volnova and Raul R. Gainetdinov. Comparative Proteomic Analysis of Heterozygous and Null DAT Knockout Rats. The present study revealed congruent results on rats with different doses of DAT gene knockout. In both knockout groups, the basic carbohydrate and energetic metabolism seems to be deregulated in the striatum compared to the WT littermates. These results are in common trend with current literature data. Expectedly, the deregulation pattern is more pronounced in homozygous DAT-KO rats than in DAT-Het. Manuscript submitted to the International Journal of Molecular Sciences. The raw mass spec data (DAT_rats_decoy) and *.mzid/Scaffold v.4.0 files (DAT_rats)