CYP51 from Acanthamoeba castellanii in complex with the tetrazole-based IND inhibitor VT-1161(VT1)
收藏Protein Data Bank Japan2026-03-04 更新2026-04-25 收录
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CYP51 from Acanthamoeba castellanii in complex with the tetrazole-based IND inhibitor VT-1161(VT1) Descriptor: (R)-2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol, PROTOPORPHYRIN IX CONTAINING FE, sterol 14a-demethylase Authors: Hargrove, T.Y, Wawrzak, Z, Lepesheva, G.I. Deposit date: 2022-09-21 Release date: 2023-08-02 Last modified: 2026-03-04 Method: X-RAY DIFFRACTION (2.29 Å) Cite: Identification of Potent and Selective Inhibitors of Acanthamoeba : Structural Insights into Sterol 14 alpha-Demethylase as a Key Drug Target. J.Med.Chem., 67, 2024
创建时间：
2022-09-21
