Inhibitor-based modulation of huntingtin aggregation mechanisms mitigates fibril-induced cellular stress

Experimental datasets for the results described in our paper "Inhibitor-based modulation of huntingtin aggregation mechanisms mitigates fibril-induced cellular stress", as reported in Nature Communications in 2025. 

Uploaded data include:

solid-state NMR spectra

SAXS results

data files for multiple cellular and biochemical assays.

See also the readme file, with contents as follows:

The files are organized by type of data, and provided as ZIP archives for each data type.

NMR data.zip

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Batch 1 fibrils: 

Figure 4a Figure 4b SI Figure 6a SI Figure 6b

Batch 2 fibrils: 

Figure 4c:SI Figure 9 (a) SI Figure 7(b)

Figure 4d: SI Figure 9 (b) SI Figure 9c

SI Figure 7(a) SI Figure 9d

SAMPLE 5:

SI Figure 10_CP SI Figure 10_INEPT

TEM Images.zip

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Figure 2 (c) Figure 2 (f) Figure 2 (i) Figure 2 (l) SI Figure 2 (e)

Figure 2 (d) Figure 2 (g) Figure 2 (j) Figure 2(m) SI Figure 10

Figure 2 (e) Figure 2 (h) Figure 2 (k) SI Figure 2 (d)

SAXS data.zip

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Figure 2n-o

Kinetics data.zip

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Figure 2a: SI 2a SI Figure 1a:b SI fluorescence data

Figure 2b: SI 2b SI Figure 1d

Results from cellular assays

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Figure3c-d_images - folder with individual image files

raw data_Figure 3.xlsx

raw data_cellular experiments.xlsx

raw data_Si Figure 4.xlsx

raw data_Sl Figure 3.xlsx