Research data supporting "Multi-channel portable odor delivery device for self-administered and rapid smell testing"

This readme file was generated on 2024-08-13 by Richard Hopper. GENERAL INFORMATION Title of Dataset: Research data supporting "Multi-channel portable odor delivery device for self-administered and rapid smell testing" Author/Principal Investigator Information Name: Richard Hopper ORCID: https://orcid.org/0000-0003-1863-9008 Institution: University of Cambridge Address: University of Cambridge Department of Engineering Electrical Engineering Division, CAPE Building, 9 JJ Thomson Avenue, Cambridge, CB3 0FA Email: [e-mail] Author/Associate or Co-investigator Information Name: Florin Udrea ORCID: https://orcid.org/0000-0002-7288-3370 Institution: University of Cambridge Address: University of Cambridge Department of Engineering Electrical Engineering Division, CAPE Building, 9 JJ Thomson Avenue, Cambridge, CB3 0FA Email: [e-mail] Date of data collection: 2023-02-01 - 2024-07-22 Geographic location of data collection: London, UK & Geneva University Hospitals Information about funding sources that supported the collection of the data: Funding for the device development was provided by OWidgets Ltd. and funding for the user study was provided by Geneva University Hospital. Funding for device characterization was provided by the Department of Engineering at the University of Cambridge. SHARING/ACCESS INFORMATION Licenses/restrictions placed on the data: CC BY-NC-ND (Creative Commons Attribution Non-Commercial No Derivatives 4.0 International licence) or CC BY (Creative Commons Attribution 4.0 International licence) licence. Links to publications that cite or use the data: "Multi-channel portable odor delivery device for self-administered and rapid smell testing" https://elements.admin.cam.ac.uk/viewobject.html?cid=1&id=1635352 Links to other publicly accessible locations of the data: n/a Links/relationships to ancillary data sets: Was data derived from another source? If yes, list source(s): n/a Recommended citation for this dataset: DATA & FILE OVERVIEW File List: File: fig2a_flow_rates.xlsx Description: Measured airflow rates for the 24 outlet channels of the odor delivery device. Measured using a Flusso FLS-110 flow sensor. File: fig2b_PID_response.xlsx Description: Transient response of the photo ionization detector (PID) to an odor exposure generated by the odor delivery device with a 3 s activation time. Response measured using an ion Science MiniPID sensor. File: fig2c_SMELL-S_odor_pulse_durations.xlsx Description: Temporal stability of the odor intensity generated by the odor delivery device over a 1 hour time window with 1 s, 2 s, 3 s, 4 s, 5 s and 6 s activation times. File: fig2d_SMELL-S_continuous_odor_pulse.xlsx Description: Temporal stability of the odor intensity generated by the odor delivery device over a 600 s (10 minute) time window with continuous activation. File: fig2e_chan_odor_intensity.xlsx Description: Channel-to-channel variation in odor intensity generated by the odor delivery device for 3 s activation times. File: fig2f_intensity_distance_x.xlsx Description: Spatial distribution of odor intensity, measured over a distance of 40 mm from the outlet of the odor delivery device, in the direction of odor flow. File: fig2g_intensity_distance_y.xlsx Description: Spatial distribution of odor intensity across the path of odor flow, measured at a distance of 100 mm from the outlet of the odor delivery device. File: fig2h_temperature_response.xlsx Description: Thermal response data giving the variation in measured odor intensity from the odor delivery device with ambient temperature. File: fig3a_SMELL-S_PID_levels.xlsx Description: Measured odor intensity for the SMELL-S odor stimuli. Relationship between files, if important: Research data used to produce figures in the paper. Additional related data collected that was not included in the current data package: Data giving the duration’s for the Sniffin’ Sticks and SMELL-S threshold tests. This data is available for medical research from the corresponding author. Are there multiple versions of the dataset? If yes, name of file(s) that was updated: n/a Why was the file updated? When was the file updated? METHODOLOGICAL INFORMATION Airflow rates from the outlet channels of the device were measured using a Flusso FLS-110 flow sensor. The average flow rate and standard deviation (SD) were derived from a set of 50 measurement cycles. Odor intensity was measured using a photo-ionisation detector (MiniPID) from Ion Science. For the measurements of stability, the sensor was positioned at a distance of 25 mm from a 4 mm diameter outlet pipe. Thermal conditions were 25 degC and the odorized airflow rate from the device was 3 L/min. The average odor intensity and standard deviation (SD) for all PID measurements were derived from a set of 10 measurement cycles. For the short pulse odor intensity repeatability tests, the odor intensity was measured using the PID gas sensor in an indoor environment over a 1 hour time window at a temperature of 25 degC, with an odor activation times repeated every 300 s. Thermal stability was measured with the device placed in an environmental oven (Thermotron S-1.2 3800). The PID gas sensor was mounted externally to the oven and odorized air fed to it from the olfactometer using 4 mm diameter pipes. Prior to each measurement, the system was left to stabilize for 30 minutes at each temperature point to ensure thermal uniformity. The spatial distribution of odor intensity was measured by mounting the PID on a motorised stage (Thorlabs, LTS300), having a reach of 300 mm. We performed a test-retest reliability and accuracy study including healthy subjects (n = 37) and patients with various causes of smell loss (n = 31) at Geneva University Hospital. The study involved subjects aged 18 years of age and over, who came to the hospital for two visits spaced approximately one week apart. During the first visit, participants were tested with the current standard test (Sniffin’ Sticks) and with SMELL-S with the smell delivery device. The order of the tests was randomized. On the second visit, the tests were repeated. We recorded the time needed to complete each test. A t-test was used to uncover differences between groups. Subjects were tested with the Sniffin’ Sticks test (Burghart, Wedel, Germany), which includes the olfactory threshold, discrimination, and identification sub-tests. The composite score of the three sub-tests was used for the classification of healthy subjects or patients with smell loss \cite{oleszkiewicz2019updated, hummel1997sniffin}. The Sniffin’ Sticks threshold subtest uses phenylethyl alcohol (rose-like odor) in pen-like odor dispensing devices. The stimuli’s have sixteen dilutions in a geometric series. Three pens were presented in a randomized order, with two containing a solvent and the third the target odorant. The subjects must identify the odor-containing pen. An experimental nurse performed a single-staircase test (with ramped odorant concentrations), with three alternative forced choice procedures starting at the most difficult level (level 16 out of 16) according to the user manual. Reversal of the staircase occurs when the odor is correctly identified in two successive trials. The olfactory threshold was defined as the mean of the last four of seven staircase reversals. Methods for processing the data: The raw data was processed using a Python script. Instrument- or software-specific information needed to interpret the data: n/a Standards and calibration information, if appropriate: The flow sensor was calibrated using a calibrated Alicat MFC at Cambridge University. Environmental/experimental conditions: Measurements were made a room temperature unless indicated. Describe any quality-assurance procedures performed on the data: The order of the smell study tests was randomized. On the second visit, the tests were repeated. People involved with sample collection, processing, analysis and/or submission: D.P and R.H. developed the experimental test setup and undertook characterisation tests, with F.U. providing technical guidance. B.N.L. and J.W.H.undertook the clinical trials with the device and analysed the results of the trial data. R.H., D.P. and J.W.H. wrote the paper. DATA-SPECIFIC INFORMATION FOR: fig2a_flow_rates.xlsx Number of variables: 2 Number of cases/rows: 24 Variable List: (1) Name: Channel, Description: Odor channel number, Units: Channels 1 - 24. (2) Name: Flow rate, Description: Airflow rates, Units: L/min. DATA-SPECIFIC INFORMATION FOR: fig2b_PID_response.xlsx Number of variables: 2 Number of cases/rows: 1 Variable List: (1) Name: Time, Description: Time from start of odor delivery device activation, Units: seconds. (2) Name: PID signal, Description: Measured odor intensity, Units: Normalised sensor response. DATA-SPECIFIC INFORMATION FOR: fig2c_SMELL-S_odor_pulse_durations.xlsx Number of variables: 2 Number of cases/rows: 6 Variable List: (1) Name: Time, Description: Time from start of odor delivery device activation, Units: minutes. (2) Name: PID signal, Description: Measured odor intensity, Units: Normalised sensor response. DATA-SPECIFIC INFORMATION FOR: fig2d_SMELL-S_continuous_odor_pulse.xlsx Number of variables: 2 Number of cases/rows: 1 Variable List: (1) Name: Time, Description: Time from start of odor delivery device activation, Units: seconds. (2) Name: PID signal, Description: Measured odor intensity, Units: Normalised sensor response. DATA-SPECIFIC INFORMATION FOR: fig2e_chan_odor_intensity.xlsx Number of variables: 2 Number of cases/rows: 24 Variable List: (1) Name: Channel, Description: Odor channel number, Units: 1 - 24. (2) Name: PID signal, Description: Measured odor intensity, Units: Normalised sensor response. DATA-SPECIFIC INFORMATION FOR: fig2f_intensity_distance_x.xlsx Number of variables: 2 Number of cases/rows: 1 Variable List: (1) Name: Distance, Description: Distance from outlet in direction of odor flow, Units: mm. (2) Name: PID signal, Description: Measured odor intensity, Units: Normalised sensor response. DATA-SPECIFIC INFORMATION FOR: fig2g_intensity_distance_y.xlsx Number of variables: 2 Number of cases/rows: 1 Variable List: (1) Name: Distance, Description: Distance across path of odor flow 100 mm from outlet, Units: mm. (2) Name: PID signal, Description: Measured odor intensity, Units: normalised sensor response. DATA-SPECIFIC INFORMATION FOR: fig2h_temperature_response.xlsx Number of variables: 2 Number of cases/rows: 1 Variable List: (1) Name: Temperature, Description: Ambient temperature, Units: Celsius. (2) Name: PID signal, Description: Measured odor intensity, Units: Normalised sensor response. DATA-SPECIFIC INFORMATION FOR: fig3a_SMELL-S_PID_levels.xlsx Number of variables: 2 Number of cases/rows: 1 Variable List: (1) Name: SMELL-S level, Description: SMELL-S difficulty level, Units: n/a. (2) Name: PID signal, Description: Measured odor intensity, Units: Normalised sensor response.