fluorescence assisted colonoscopy for detection of bowel polyps

Primary objectives: To assess the efficacy of 0.13mg/kg EMI-137 IV injection to detect lesions during colonoscopy, in subjects at high suspicion of developing colorectal cancer by:- Comparing the number of pathological lesions detected with WL with the number of lesions detected with WL+FL- Investigating the concordance of fluorescence intensity, C-Met expression and histologic status.- Establishing target to background ratio (TBR) of fluorescent lesions.
Primary endpoints: Efficacy- Detection of additional pathological lesions using WL+ FL compared to WL only- Fluorescence signal of lesions- TBR signal, defined as fluorescent signal of the lesion compared to fluorescence signalof tissue surrounding the lesion- Concordance between fluorescence, tumor status and C-Met expression.