Cancer stem cells (CSCs) are attractive targets for cancer therapy, however, little is known about how to target CSCs without affecting the normal stem cell population. Here we report the ribosome-pro

NIAID Data Ecosystem70

Combined inhibition of EZH2 and CDK4/6 perturbs endoplasmic reticulum-mitochondrial 1 homeostasis and increases antitumor activity against glioblastoma

胶质瘤靶向治疗

线粒体功能与细胞稳态

Background: Few druggable targets have been discovered in glioblastoma (GBM); however, increasing knowledge has uncovered two hallmarks of this disease: epigenetic modifications and cell cycle dysregu

NIAID Data Ecosystem20

Correction: Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma

胶质瘤靶向治疗

mTOR信号通路

Correction: Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma

NIAID Data Ecosystem80

Evaluation of Tyrosine Kinase Inhibitor Combinations for Glioblastoma Therapy

胶质瘤靶向治疗

酪氨酸激酶抑制剂组合疗效

Glioblastoma multiforme (GBM) is the most common intracranial cancer but despite recent advances in therapy the overall survival remains about 20 months. Whole genome exon sequencing studies implicate

Figshare2016-01-19 更新20

Reverse phase protein arrays (RPPAs): effects of MPS1 inhibition on signaling pathways in GBM cells

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