Cloning and expression of two brain-specific inwardly rectifying potassium channels.
收藏PubMed Central1995-07-18 更新2026-05-02 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC41407/
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资源简介：
We have cloned two inwardly rectifying K+ channels that occur selectively in neurons in the brain and are designated BIRK (brain inwardly rectifying K+) channels. BIRK1 mRNA is extremely abundant and is enriched in specific brainstem nuclei, BIRK1 displays a consensus phosphate-binding loop, and expression in Xenopus oocytes has shown that its conductance is inhibited by ATP and adenosine 5'-[gamma-thio]triphosphate. BIRK2 is far less abundant and is selectively localized in telencephalic neurons. BIRK2 has a consensus sequence for cAMP-dependent phosphorylation. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1995-07-18
