16S microbial sequences from mice from a variety of treatments. mouse gut metagenome

Colorectal cancer is a leading cause of cancer-related deaths. Mutations in the innate immune receptor AIM2 are frequently identified in patients with colorectal cancer, but how AIM2 modulates colonic tumorigenesis is unknown. This study aims to investigate the synergy between this host genetic factor and gut microbiota in determining the susceptibility to colorectal cancer.