CircRNA Expression Profiling of the Rat Thalamus In Temporomandibular Joint Chronic Inflammatory Pain

Differential expression of circular RNAs (DEcircRNAs) in the thalamus, a relay station of the orofacial pain transmission pathway, may play an important role in inflammation and inflammatory pain progression in TMJOA and serve as a potential marker for its targeting. In this study, we obtained the expression profile of circRNAs from the thalamus of the rat TMJOA model by high-throughput sequencing to explore the potential role of circRNA in TMJOA inflammation and chronic inflammatory pain progression and their potential as new targeted molecular markers. Additionally, providing new clues to unravel the molecular mechanisms of chronic orofacial pain, providing insights into the potential roles of circRNAs in pain modulation, and paving the way for future research in this area.