Oxt

This gene encodes a preproprotein that is processed to produce oxytocin and neurophysin 1. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin 1. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation, the stress response and complex sexual and maternal behavior, as well as in the regulation of water excretion, salt appetite, blood pressure and cardiovascular functions. Deletion of this gene in mouse reduces bone formation resulting in osteoporosis. [provided by RefSeq, Dec 2013]

本基因编码一种前体蛋白，经加工后生成催产素和神经肽1。催产素为垂体后叶激素，在脑垂体中与携带蛋白神经肽1一同合成，作为无活性的前体。与神经肽共同封装于神经分泌囊泡中，通过轴突运输至神经垂体末梢，此处激素可储存或分泌入血液循环。前体蛋白在沿轴突向垂体后叶运输的过程中似乎被激活。此激素在分娩和哺乳过程中收缩平滑肌。此外，催产素还参与认知、耐受、适应、应激反应、复杂的性及母性行为，以及水分排泄、盐分食欲、血压和心血管功能的调节。小鼠此基因的缺失会导致骨形成减少，进而引发骨质疏松。[由RefSeq提供，2013年12月]

搜集汇总

背景与挑战

背景概述

该数据集描述了基因Oxt，它编码一种前体蛋白，可加工生成催产素和神经垂体素1。催产素是后垂体激素，参与平滑肌收缩、认知、应激反应等多种生理过程，且在老鼠中其缺失会导致骨形成减少和骨质疏松。