Identification of a sacral, visceral sensory transcriptome in embryonic and adult mice

This collection comprises three sets of transcriptome data (bulk RNAseq) focused on primary sensory neurons in mouse dorsal root ganglia. Data was collected from adult wildtype mice, adult Trpv1 reporter mice (Trpv1PLAP-nLacZ) and E18.5 wildtype mouse embryos. In each group, ganglia from specific spinal levels were selected to enable direct comparison of mixed visceral/somatic ganglia (L6-S1) with the adjacent purely somatic ganglia (L4-L5). This enables identification of features unique to visceral neurons that innervate the pelvic organs. The majority of these sensory neurons innervate the lower urinary tract and lower bowel, with a smaller population innervating reproductive organs. The study was performed in both males and females to identify potential sex differences in the sensory transcriptome.