Vitamin B12 metabolism

Vitamin B12 is a water soluble, organic compound and essential nutrient involved in the everyday functioning of the nervous system and the brain. Vitamin B12 is involved in the preservation and regeneration of the myelin shealth - the protective fatty layer that acts as an insulator in nerve axons. Animals store vitamin B12 in liver and muscle and therefore eggs, milk, meat, liver are sources of the vitamin. Problems in metabolism of vitamin B12 lead to "persistent" lack of energy to perform every day tasks. The genes and pathways highlighted above describe several routes through which genes and metabolites involved in B12 metabolism are interconnected. Central B12 metabolism nodes include folate metabolism and the synthesis of the citric acid cycle intermediates and succinyl-CoA, cyanocobalamin into methylcobalamin conversion, tyrosine nitration and riboflavin pathways.

维生素B12是一种可溶于水的有机化合物，是维持神经系统及大脑日常功能所必需的营养素。维生素B12在维持和再生髓鞘——一种在神经轴突中充当绝缘体的保护性脂肪层——的过程中发挥着关键作用。动物在肝脏和肌肉中储存维生素B12，因此鸡蛋、牛奶、肉类和肝脏成为该维生素的重要来源。维生素B12代谢问题会导致能量“持续”不足，从而影响日常任务的执行。上述突出的基因和通路描述了多个基因和代谢物在维生素B12代谢中相互连接的途径。维生素B12的中心代谢节点包括叶酸代谢、柠檬酸循环中间产物和琥珀酰辅酶A的合成、氰钴胺素转化为甲基钴胺素、酪氨酸硝化和核黄素途径。